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Anterograde transneuronal viral tract tracing reveals central sensory circuits from brown fat and sensory denervation alters its thermogenic responses

Brown adipose tissue (BAT) thermogenic activity and growth are controlled by its sympathetic nervous system (SNS) innervation, but nerve fibers containing sensory-associated neuropeptides [substance P, calcitonin gene-related peptide (CGRP)] also suggest sensory innervation. The central nervous syst... (original story)

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Multidisciplinary care in the intensive care unit for a patient with Prader-Willi syndrome: a dental approach

This study aims to report on a case involving a white male 15-year-old patient with Prader-Willi syndrome whose oral examination revealed bacterial plaque, gingivitis, poor occlusion, viscous salivation and multiple lip, jugal mucosa, inserted gum and tongue ulcerations. An excision biopsy revealed ... (original story)

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Infectious causes of posterior uveitis and panuveitis in Thailand

Conclusions  CMV was the most frequently identified infectious organism in posterior and panuveitis of HIV-1-negative Thai patients. Aqueous humor and vitreous samples showed similar diagnostic values in PCR analysis. Content Type Journal ArticleCategory Clinical InvestigationPag... (original story)

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Biological basis for the protective effect conferred by male circumcision against HIV infection

Here we provide an up-to-date review of research that explains why uncircumcised men are at higher risk of HIV infection. The inner foreskin is a mucosal epithelium deficient in protective keratin, yet rich in HIV target cells. Soon after sexual exposure to infected mucosal secretions of a HIV-posit... (original story)

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Epidemiological characteristics and societal burden of varicella zoster virus in the Netherlands

Conclusions: For varicella the highest incidence of GP-consultations was found in 1-4 year-olds, for herpes zoster in the >65 years olds. The occurrence of complications was not age-dependent but varies per complication. When estimating incidence of VZV-related diseases in primary care, based on dia... (original story)

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Many cancers caused by 'treatable infections'

Conclusion This important study highlights the potential role played by certain infections in causing cancer. It uses the highest quality available evidence to calculate the proportion of cancer caused by infectious agents, worldwide and by region. However, as the authors point out, their calculatio... (original story)

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Epithelial immunity by resident memory T cells [Immunology]

In this study, we demonstrate that long-lived intraepithelial CD103+CD8+ TRM cells can be generated in the absence of in situ antigen recognition. Local inflammation in skin and mucosa alone resulted in enhanced recruitment of effector populations and their conversion to the TRM phenotype. The CD8+ ... (original story)

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Increased plasma LIGHT levels in patients with atopic dermatitis.

We examined plasma LIGHT levels, total serum IgE, serum value of CCL17 and peripheral blood eosinophil counts in patients with AD and healthy subjects. The effects of LIGHT on activation and apoptosis in THP-1 cells were also investigated. The plasma concentrations of LIGHT in AD patients were signi... (original story)

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PILR{alpha}/Ligands Interaction [Molecular Biophysics]

Paired immunoglobulin-like receptor (PILR) α is an inhibitory receptor that recognizes several ligands, including mouse CD99, PILR-associating neural protein, and Herpes simplex virus-1 glycoprotein B. The physiological function(s) of interactions between PILRα and its cellular ligands are not wel... (original story)

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Clinical impact of HSV‐1 detection in the lower respiratory tract from hospitalized adult patients

Clin Microbiol InfectAbstractThe occurrence and clinical impact of herpes simplex virus (HSV) were evaluated in 342 bronchoalveolar lavage specimens from 237 patients. HSV‐1 and HSV‐2 were detected in 32.1% and <1% of patients, respectively. A significant difference of HSV‐1 prevalence and loa... (original story)

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