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Development and evaluation of a monolithic floating drug delivery system for acyclovir.

Posted from MedWorm: Herpes 105 days ago
Herpes : Herpes Articles

Authors: Tavakoli N, Varshosaz J, Dorkoosh F, Motaghi S, Tamaddon L Abstract Acyclovir (ACV), a model drug for this study, is one of the most effective drugs against viruses of the herpes group. Absorption of orally administered ACV is variable and incomplete, with a bioavailability of ca. 15-30%. The drug is absorbed in the duodenum after oral administration and hence, preparation of a floating drug delivery system (FDDS) for ACV may increase oral absorption of the drug. ACV matrix tablets (200 mg) containing an effervescent base (sodium bicarbonate and citric acid) and a binary com... (original story)